Evidence Based Hair
Evidence based hair is a weekly podcast hosted by Dr Jeff Donovan, a Canadian dermatologist and hair specialist. Each week, Dr. Donovan highlights recently published hair loss research from around the world.
Episodes
Friday Dec 22, 2023
Top 20 Hair Research Studies of 2023
Friday Dec 22, 2023
Friday Dec 22, 2023
This is a recording from the live webinar was conducted live December 13, 2023. This is an annual event that is held every year in mid-December celebrating the top hair research studies.
DERMATOPATHOLOGY
Douglas A et al. Scalp Biopsy Influences Diagnostic Accuracy and Treatment in Black Women with Alopecia: A Retrospective Study. J Am Acad Dermatol. 2023 Jan 31;S0190-9622(23)00157-3.
ANDROGENETIC ALOPECIA
Gupta AK et al.The relative efficacy of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta-analysis study. J Cosmet Dermatol. 2023 Jun 29
Jimenez-Cauhe J et al. Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.
ALOPECIA AREATA
Gandhi et al.The Association of Alopecia Areata-Related Emotional Symptoms with Work Productivity and Daily Activity Among Patients with Alopecia Areata. Dermatol Ther (Heidelb). 2023 Jan;13(1):285-298.
Li SJ et al. Experiencing Workplace Bullying in Patients with Alopecia Areata: A Cross-Sectional Survey Study. Skin Appendage Disord. 2023 Aug;9(4):258-261
Kazmi A et al. Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.
King B et al. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b-3 trial. Lancet. 2023 May 6;401(10387):1518-1529.
George P et al. Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.
Wang C-W et al. Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations. Clin Immunol. 2023 Oct:255:109737.
Chen J et al. The Incidence of Alopecia Areata in a COVID-19- Vaccinated Population: A Single-Center Review. Cureus 2023
TELOGEN EFFLUVIUM
Michelini S et al. Telogen Effluvium in SARS-CoV-2 Infection: histological aspects. J Eur Acad Dermatol Venereol. 2023 Mar 8.
TINEA CAPITIS
Gold, JA et al. Inadequate diagnostic testing and systemic antifungal prescribing for tinea capitis in an observational cohort study of 3.9 million children, United States. J Am Acad Dermatol. 2023 Feb 15;S0190-9622(23)00189-5.
COSMETIC DERMATOLOGY
Landau M et al. Nonscarring alopecia after temporal lifting technique with dermal fillers. JAAD Case Rep. 2023 May 12;37
FOLLICULITIS DECALVANS
Matard B et al. Folliculitis decalvans and dystrophic epidermolysis bullosa: a significant association. Br J Dermatol 2022 Dec;187(6):1026-1028.
DISCOID LUPUS
Fredeau L et al. Risk factors of progression from discoid lupus to severe systemic lupus erythematosus: a registry-based cohort study of 164 patients. J Am Acad Dermatol. 2023 Mar;88(3):551-559.
DISSECTING CELLULITIS
Cajas-Garcia MS et al. Distinct presentations of scalp dissecting cellulitis manifesting with furrows and gyri. J Eur Acad Dermatol Venereol. 2023 Feb 3.
LICHEN PLANOPILARIS Lim SH et al. Prevalence and Incidence of Comorbid Diseases and Mortality Risk Associated with Lichen Planopilaris: A Korean Nationwide Population-Based Study. Clin Exp Dermatol. 2023 Jul 11;llad235
GENERAL SCARRING ALOPECIA
Kim SR et al. Association of Primary Cicatricial Alopecia with Subsequent Cardiovascular Disease. J Invest Dermatol. 2023 Nov 19:S
CENTRAL CENTRIFUGAL CICATRICIAL ALOPECIA
Joshi TP et al. Comorbidities in patients with central centrifugal cicatricial alopecia: a case-control study. Int J Dermatol. 2023 Nov 23.
ACNE KELOIDALIS NUCHAE
Lobato-Berezo A et al. Acne keloidalis nuchae: An international multicentric review of 79 patients. J Eur Acad Dermatol Venereol. 2023 Nov 1.
Monday Dec 04, 2023
Monday Dec 04, 2023
Monday Nov 27, 2023
Season 6, Episode 6 (Alopecia Areata Triggered by COVID19 Vaccination)
Monday Nov 27, 2023
Monday Nov 27, 2023
STUDIES REFERENCED IN THIS EPISODE
Pastukhova E et al. Alopecia Areata as a Sequela of COVID-19 Vaccination: A Systematic Review J Cutan Med Surg. 2023 Jan-Feb;27(1):64-65.
Wang C-W et al. Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations. Clin Immunol. 2023 Oct:255:109737.
Genco L et al. Alopecia Areata after COVID-19 Vaccines. Skin Appendage Disord. 2023 Mar;9(2):141-143.
Wednesday Nov 22, 2023
Season 6, Episode 5 (COVID 19 Infection and the Risk of Autoimmune Disease)
Wednesday Nov 22, 2023
Wednesday Nov 22, 2023
STUDIES REVIEWED THIS WEEK:
Chang R et al. Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study. EClinicalMedicine. 2023 Feb;56:101783
Tesch F et al. Incident autoimmune diseases in association with SARS-CoV-2 infection: a matched cohort study. Clin Rheumatol. 2023 Oct;42(10):2905-2914.
Lim SG et al. Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19 JAMA Netw Open. 2023 Oct 2;6(10):e2336120.
Pastukhova E et al. Alopecia Areata as a Sequela of COVID-19 Vaccination: A Systematic Review J Cutan Med Surg. 2023 Jan-Feb;27(1):64-65.
STUDIES TO BE REVIEWED NEXT WEEK (PREVIEW)
Wang C-W et al. Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations. Clin Immunol. 2023 Oct:255:109737.
Genco L et al. Alopecia Areata after COVID-19 Vaccines. Skin Appendage Disord. 2023 Mar;9(2):141-143.
Monday Nov 13, 2023
Season 6 Episode 4 (Baricitinib for CCCA, LED laser therapy for CCCA)
Monday Nov 13, 2023
Monday Nov 13, 2023
STUDIES REFERENCED IN THIS EPISODE:
Workman K and Kindred C (starts at 2:10). Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib. JAAD Case Rep. 2023 Jul 28:39:109-111.
Cook M et al (starts at 12:07). Use of low-level light therapy in management of central centrifugal cicatricial alopecia: A case series of four patients. Photodermatol Photoimmunol Photomed. 2023 Aug 23.
Monday Nov 06, 2023
Monday Nov 06, 2023
ARTICLES COVERED THIS WEEK
STUDY 1:
Ong M et al (starts at 5:12). Low-dose oral minoxidil for androgenetic alopecia is not associated with clinically significant blood-pressure changes: a retrospective study. J Am Acad Dermatol. 2023 Oct 13:S0190-9622(23)02976-6.
Sanabria et al. Prospective cardiovascular evaluation with 24-h Holter and 24-h ambulatory blood pressure monitoring in men using 5 mg oral minoxidil for androgenetic alopecia. J Am Acad Dermatol. 2022 May 18;
Jimenez-Cauhe J et al. Before-after study with 24-hour ambulatory blood pressure monitoring after the first dose of 5 mg oral minoxidil. J Am Acad Dermatol. 2022 Dec;87(6):e235-e237
STUDY 2:
Imhof R et al (starts at 16:35). Safety and tolerability of low dose oral minoxidil monotherapy in female pattern hair loss: A retrospective review with longitudinal ambulatory blood pressure monitoring. JAAD Int. 2023 Aug 12:13:50-52.
Ramos PM et al. Minoxidil 1 mg versus minoxidil 5 % topical solution for the treatment of female-pattern hair loss: A randomized clinical trial. J Am Acad Dermatol Jan 2020;82(1):252-253.
STUDY 3:
Jimenez-Cauhe J et al (starts at 24:27). Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.
Vano-Galvan S et al. Safety of low dose oral minoxidil for hair loss: A multicenter study of 1404 patients. JAAD 2021; 84: 1644-51.
Sanabria B et al. Adverse effects of low dose oral minoxidil for
androgenetic alopecia in 435 patients. JAAD 2021; 84: 1175-78.
ARITCLES COVERED NEXT WEEK (PREVIEW)
Cook M et al. Use of low-level light therapy in management of central centrifugal cicatricial alopecia: A case series of four patients. Photodermatol Photoimmunol Photomed. 2023 Aug 23.
Workman K and Kindred C. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib. JAAD Case Rep. 2023 Jul 28:39:109-111
Saturday Nov 04, 2023
Saturday Nov 04, 2023
ARTICLES REFERENCED IN THIS EPISODE
Krauss A (starts at 12:44). Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.
Van Noreen R (starts at 15:33). Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at https://youtu.be/_QLvzCr6nz4?feature=shared
Carlisle JB (starts at 16:28). False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.
PREVIEW STUDIES FOR NEXT WEEK (SEASON 6, EPISODE 3)
Ong M et al. Low-dose oral minoxidil for androgenetic alopecia is not associated with clinically significant blood-pressure changes: a retrospective study. J Am Acad Dermatol. 2023 Oct 13:S0190-9622(23)02976-6. doi: 10.1016/j.jaad.2023.10.010. Online ahead of print.
Jimenez-Cauhe et al. Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.
Imhof R et al. Safety and tolerability of low dose oral minoxidil monotherapy in female pattern hair loss: A retrospective review with longitudinal ambulatory blood pressure monitoring. JAAD Int. 2023 Aug 12:13:50-52.
Tuesday Oct 24, 2023
Tuesday Oct 24, 2023
Studies Referenced in This Episode: Season 6 Episode 1
King B et al (starts at 4:07). When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials. Br J Dermatol. 2023 Sep 14:ljad253.
Gargiulo L et al (starts at 30:22). Effectiveness and safety of baricitinib in patients with severe alopecia areata: a 36-week multicenter real-world experience. J Dermatolog Treat. 2023 Dec;34(1):2268764.
Preview of Studies for New Week: Season 6 Episode 2
Krauss A. Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.
Carlisle JB. False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.
Van Noorden R. Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at https://youtu.be/_QLvzCr6nz4?feature=shared
Sunday Oct 01, 2023
Sunday Oct 01, 2023
On August 1, 2023, Dr Donovan announced the long awaited start of the Evidence Based Hair Fellowship training program. This is an online (virtual) training program for practitioners that wish to develop expertise in hair loss. The program runs Jan 2024 to August 2025 and participants meet once weekly for a three hour period (either on a Wednesday or a Thursday).
In this short recording, Dr Donovan updated listeners on the Evidence Based Hair Fellowship training program.
Interested participants may wish to watch video describing the full program at https://youtu.be/xWBT9sKWU_k?si=6TVCHw3lnNgb2_mk
or download the coarse syllabus at:
https://donovanmedical.com/donovan-hair-academy
Sunday Sep 10, 2023
Sunday Sep 10, 2023
Alopecia Areata Awareness Month - Recording from Sept 6 2023 Live Public Webinar hosted by Dr Donovan.
Question 1 (starts at 3:50): Is the rate of alopecia areata going up ?
Question 2 (starts at 7:45). What blood tests should be ordered for someone with alopecia areata?
Question 3 (starts at 11:58). Do JAK inhibitors cure alopecia areata?
Question 4 (starts at 15:45). What treatments are possible for eyelash loss?
Question 5 (starts at 17:53). What other medical problems do patients with alopecia areata have?
Question 6 (starts at 20:29). My son is 3 years old and Alopecia. 1 year ago, hair loss started and his hair and eyebrows completely fell out. In the tests , it was determined that his intestinal flora was very disordered and he has lactose and gluten intolerance. There are some doctors who have found that Intestinal Flora Disorder and Leaky Gut Syndrome can cause some autoimmune diseases. I would like to know your thoughts on this subject.
Question 7 (starts at 26:58). Should I ask for a biopsy to prove the diagnosis of alopecia areata?
Question 8 (starts at 29:01). I am a 37 year old female and have alopecia areata. Will I pass this on to my children?
Question 9 (starts at 31:48). Does stress cause alopecia areata? I hear mixed views.
Question 10 (starts at 35:16). My 3 year old developed a small area of alopecia over the summer. What treatment is considered best?
Question 11 (starts at 41:12). Does low vitamin D make alopecia worse?
Question 12 (starts at 43:43). Myalopecia areata is becoming scarring. How is this possible?
Question 13 (starts at 47:13). Do you see loss of efficacy over time of JAK inhibitors and if so what would be the reason