Evidence Based Hair

Season 6 Episode 1 (Baricitinib Response Timing, Real World Study of Baricitinib)

Studies Referenced in This Episode: Season 6 Episode 1
King B et al (starts at 4:07). When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials. Br J Dermatol. 2023 Sep 14:ljad253.
 
Gargiulo L et al (starts at 30:22). Effectiveness and safety of baricitinib in patients with severe alopecia areata: a 36-week multicenter real-world experience. J Dermatolog Treat. 2023 Dec;34(1):2268764.
 
 
Preview of Studies for New Week: Season 6 Episode 2
 
Krauss A. Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.
 
Carlisle JB. False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.
 
Van Noorden R. Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at https://youtu.be/_QLvzCr6nz4?feature=shared

Reminder of December 1, 2023 Deadline For Evidence Based Hair FellowshipTraining Program for Hair Loss Practitioners

On August 1, 2023, Dr Donovan announced the long awaited start of the Evidence Based Hair Fellowship training program. This is an online (virtual) training program for practitioners that wish to develop expertise in hair loss. The program runs Jan 2024 to August 2025 and participants meet once weekly for a three hour period (either on a Wednesday or a Thursday).
In this short recording, Dr Donovan updated listeners on the Evidence Based Hair Fellowship training program. 
 
Interested participants may wish to watch video describing the full program at https://youtu.be/xWBT9sKWU_k?si=6TVCHw3lnNgb2_mk
 
or download the coarse syllabus at:
https://donovanmedical.com/donovan-hair-academy
 

Alopecia Areata Awareness Month - Recording from Sept 6 2023 Live Public Webinar

Alopecia Areata Awareness Month - Recording from Sept 6 2023 Live Public Webinar hosted by Dr Donovan.
Question 1 (starts at 3:50): Is the rate of alopecia areata going up ?
 
Question 2 (starts at 7:45). What blood tests should be ordered for someone with alopecia areata?
 
Question 3 (starts at 11:58). Do JAK inhibitors cure alopecia areata?
 
Question 4 (starts at 15:45). What treatments are possible for eyelash loss?
 
Question 5 (starts at 17:53). What other medical problems do patients with alopecia areata have?
 
Question 6 (starts at 20:29). My son is 3 years old and Alopecia. 1 year ago, hair loss started and his hair and eyebrows completely fell out. In the tests , it was determined that his intestinal flora was very disordered and he has lactose and gluten intolerance. There are some doctors who have found that Intestinal Flora Disorder and Leaky Gut Syndrome can cause some autoimmune diseases. I would like to know your thoughts on this subject.
 
Question 7 (starts at 26:58). Should I ask for a biopsy to prove the diagnosis of alopecia areata?
 
Question 8 (starts at 29:01). I am a 37 year old female and have alopecia areata. Will I pass this on to my children?
 
Question 9 (starts at 31:48). Does stress cause alopecia areata? I hear mixed views.
 
Question 10 (starts at 35:16). My 3 year old developed a small area of alopecia over the summer. What treatment is considered best?
 
Question 11 (starts at 41:12). Does low vitamin D make alopecia worse?
 
Question 12 (starts  at 43:43). Myalopecia areata is becoming scarring. How is this possible?
 
Question 13 (starts at 47:13). Do you see loss of efficacy over time of JAK inhibitors and if so what would be the reason

Season 5, Episode 6 (Selenium Toxicity, Alopecia Neoplastica, Lymphema Distichiasis Syndrome, Eyebrow Hypotrichosis, Seasonal Shedding)

Season 5 Ep 6

Season 5, Episode 5 (CCCA Prognosis, CCCA in Males, Anagen Hairs in LPP, EPDS and NMSC and FD in Females)

STUDIES REFERENCED IN THIS EPISODE
Onamusi T et al (starts at 8:58). Clinical factors and hair care practices influencing outcomes in central centrifugal cicatricial alopecia. Arch Dermatol Res. 2023 May 15. doi: 10.1007/s00403-023-02630-5. Online ahead of print.
 
Erinolaoluwa F et al (starts at 11:59). Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. JAAD Case Reports Feb 2020
 
Jackson TK et al (starts at 15:40). Central Centrifugal Cicatricial Alopecia in Males. J Am Acad Dermatol. 2023 Jul 24:S0190-9622(23)02399-X.
 
Melo RR et al (starts at 21:45). Positive Anagen Pull Test Predicting Lichen Planopilaris Activity. Dermatol Pract Concept. 2023 Jul 1;13(3):e2023140.
 
Shamloul N et al (starts at 29:14). Incidence and time to development of malignancies arising on the scalp of patients with erosive pustular dermatosis based on sex: A retrospective analysis. J Am Acad Dermatol. 2023 Jun 13;S0190-9622(23)01111-8.
 
Negbenebor NA et al (starts at 34:45). Nonmelanoma skin cancer in the setting of erosive pustular dermatosis of the scalp: A case series and comment on management implications. Dermatol Ther. 2022 Jul;35(7):e15584. doi: 10.1111/dth.15584. Epub 2022 May 28.
 
Sarkis A et al (starts at 41:54). Folliculitis Decalvans in women: a retrospective multicenter study of 150 patients. J Eur Acad Dermatol Venereol. 2023 Aug 18.
 
Vañó-Galván S et al (starts at 43:39). Folliculitis decalvans: a multicentre review of 82 patients. J Eur Acad Dermatol Venereol. 2015 Sep;29(9):1750-7.

Season 5, Episode 4 (Switching JAK Inhibitors, Ritlecitinib in Adolescents, VTE Risk in AT/AU, Habit Replacement Therapy in TTM)

STUDIES REFERENCE IN THE EPISODE
 
SWITCHING FROM TOFACITINIB TO BARICITINIB
 
Kazmi A et al (starts at 12:33). Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.
 
 
RITLECITINIB IN ADOLESCENTS
 
Hordinsky M et al (starts at 21:31). Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double-blind, placebo-controlled trial. Pediatr Dermatol. 2023 Jul 17.
 
 
RISK OF INFECTIONS, CANCER, HEART DISEASE AND BLOOD CLOTS IN AT/AU
 
George P et al (starts at 36:08). Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.
 
 
Schneeweiss MC et al (starts at 37:36). Incidence of Venous Thromboembolism in Patients With Dermatologist-Diagnosed Chronic Inflammatory Skin Diseases. JAMA Dermatol. 2021 Jul 1;157(7):805-816.
 
 
MARKERS OF VENOUS THROMBOEMBOLISM IN ALOPECIA AREATA
 
Sudnik W et al (starts at 57:40) . The role of selectins in alopecia areata. Postepy Dermatol Alergol. 2015 Feb;32(1):27-32.
 
Shakoei S et al (starts at 58:23). Coagulation status in patients with alopecia areata: a cross-sectional study. Ital J Dermatol Venerol. 2021 Oct;156(5):588-592.
 
Waśkiel-Burnat A et al (starts at 59:30). Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry about? Dermatol Ther (Heidelb). 2023 Aug;13(8):1847-1855.
 
 
HABIT REPLACEMENT THERAPY FOR TRICHOTILLOMANIA
 
Moritz S et al (starts at 1:04:34). Self-Help Habit Replacement in Individuals With Body-Focused Repetitive Behaviors: A Proof-of-Concept Randomized Clinical Trial.  JAMA Dermatol. 2023 Jul 19;e232167.
 
LINK TO VIDEO on HRT DEMONSTRATION https://clinical-neuropsychology.de/habit-replacement-en/#sthash.J6iQiYRi.dpuf
 
 

Season 5, Episode 3 (Ranking of Finasteride and Minoxidil Protocols for FPHL, Follow up to New York Times Aug 2022 Article, Periorbital Edema from Oral Minoxidil, TE from Anticonvulsant Medications)

Season 5, Episode 2 (CVG secondary to Psoriasis, Hair Loss from Temporal Lifts, Oral minoxidil Lung Disease, PTSD & Autoimmunity, Laser Hair Removal & Behcet’s)

NON SCARRING ALOPECIA AFTER HYALURONIC ACID TEMPORAL LIFTING TECHNIQUES
Landau M et al (starts at 9:05). Nonscarring alopecia after temporal lifting technique with dermal fillers. JAAD Case Rep. 2023 May 12;37:30-34
Coimbra D.D., and de Oliveira B.S (starts at 10:17). Supra-auricular lifting with fillers: new technique. J Cosmet Dermatol. 2016;8(4):328–335.
 
CUTIS VERTICES GYRATA DUE TO PSORIASIS
Garcia-Rodriquez V et al (starts at 25:19). Cutis verticis gyrata secondary to scalp psoriasis. Int J Dermatol. 2023 Jun 4.
 
ORAL MINOXIDIL ASSOCIATED HYPERSENSITIVITY PNEUMONITIS
Takekosh D et al (starts at 32:35). Minoxidil-induced lung disease, masquerading as hypersensitivity pneumonitis. Respir Med Case Rep. 2023 Apr 29;43:101861.
 
PTSD AND AUTOIMMUNE DISEASE
Hsu TW et al (starts at 43:40). Risk of autoimmune diseases after post-traumatic stress disorder: A nationwide cohort study. Eur Arch Psychiatry Clin Neurosci. 2023 Jun 15.
 
Song H et al (starts at 49:18). Association of Stress-Related Disorders With Subsequent Autoimmune Disease. JAMA. 2018 Jun 19;319(23):2388-2400.
 
Dai Y-X et al (starts at 51:00). Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases: A Nationwide Population-Based Cohort Study. Psychosom Med. 2021 Apr 1;83(3):212-217.
 
PATHERGY IN PATIENTS WITH BEHCET’S DISEASE RECEIVIGING LASER HAIR REMOVAL R
Nicolau et al (starts at 53:07). Pathergy-like reaction induced by laser hair removal in a patient with Behçet disease. Reumatismo. 2023 Jul 17;75(2).
Van der Ree-Pellikaan C et al (starts at 1:01:48). Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behçet's disease. BMJ Case Rep. 2016 Mar 7;2016:bcr2014209208. doi: 10.1136/bcr-2014-209208.

Season 5 Episode 1 (LPP Disease Associations, LPP & Thyroid, Side Effects of HCQ, Genetic Basis of Male FFA, FFA Prevalence/Incidence)

DISEASE ASSOCIATIONS IN FRONTAL FIBROSING ALOPECIA
Conic et al. Exploring the association between lichen planopilaris, cardiovascular and metabolic disorders. J Eur Acad Dermatol Venereol 2021 Nov;35(11):e826-e828. 
 
Joshi et al. Comorbidities associated with lichen planopilaris: a case-control study using the All of Us database. Int J Dermatol. 2022 Oct 2.
 
Lim SH Prevalence and Incidence of Comorbid Diseases and Mortality Risk Associated with Lichen Planopilaris: A Korean Nationwide Population-Based Study. Clin Exp Dermatol. 2023 Jul 11;llad235
 
 
THE RELATIONSHIP BETWEEN LPP AND HYPOTHYROIDISM
 
Joshi TP et al. Association of lichen planopilaris with hypothyroidism: a systematic review and meta-analysis. Int J Dermatol. 2023 Jul 10.
 
 
SIDE EFFECTS OF HYDROXYCHLOROQUINE IN PATIENTS WITH SCARRING ALOPECIA  
 
Ezemma O et al. Adverse effects of hydroxychloroquine use in patients with cicatricial alopecia: A systematic review. Int J Dermatol. 2023 Apr 10. doi: 10.1111/ijd.16660. Online ahead of print
 
 
GENETICS OF MALE FRONTAL FIBROSING ALOPECIA
 
Rayinda T et al. Shared Genetic Risk Variants in Both Male and Female Frontal Fibrosing Alopecia. J Invest Dermatol. 2023 May 19;S0022-202X(23)02068-7.
 
 
 
INCIDENCE AND PREVALENCE OF FRONTAL FIBROSING ALOPECIA
 
Lavian J et al. Incidence estimates for lichen planopilaris and frontal fibrosing alopecia in a New York City health care system. Dermatol Online J. 2021 Aug 15;27(8).
 
Trager MH et al. Prevalence estimates for lichen planopilaris and frontal fibrosing alopecia in a New York City health care system. J Am Acad Dermatol 2021 Apr;84(4):1166-1169
 
Carmona-Rodriquez M et al. Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases. Life (Basel). 2023 Jun 8;13(6):1344.

Season 4, Episode 8 (Isotretinoin for SD, Iron Therapy, Memantine for TTM, Antifungal Resistance

Season 4, Episode 8