Evidence Based Hair

Season 2, Episode 2 (Oral Minoxidil, Sarcoidosis, JAK inhibitor safety and Trichomegaly)

Recording of the Evidence Based Hair Podcast for the May 23, 2022 issue. 
ORAL MINOXIDIL USE IN PEDIATRIC PATIENTS
 
Nicolas-Ruanes et al (starts at 4:00). Low-dose oral minoxidil for treatment of androgenetic alopecia and telogen effluvium in a pediatric population: A descriptive study. J Am Acad Dermatol. 2022 Apr 26;
 
Jerjen R et al. Low-dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome. Br J Dermatol. 2021;184(5):977-978.
 
 
ORAL MINOXIDIL COMPOUNDING ERRORS
 
Moreno-Arrones OM et al (starts at 9:06). Serious Adverse effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment. Actas Dermosifiliogr. 2022 May 12;S0001-7310(22)00414-8.
 
 
DOXYCYCLINE SKIN PIGMENTATION
 
Afrin et al (starts at 17:15). Doxycycline-Associated Hyperpigmentation: A Case Report and Literature Review. Cureus.  2022 Apr 2;14(4):e23754.
 
 
SCALP SARCOIDOSIS
Kim JC and Lee ES (starts at 22:06). Unusual Case of Scalp Sarcoidosis with Alopecia: An Only Manifestation of Cutaneous Sarcoidosis without Systemic Involvement. Ann Dermatol. 2022 Apr;34(2):154-156.
 
Long T et al. Severe scalp sarcoidosis in an unlikely patient. JAAD Case Rep. 2020 Apr 24;6(11):1165-1166.
 
House NS et al. Sarcoidosis-induced alopecia.Dermatol Online J 2012 Aug 15;18(8):4.  
 
Ghosh A et al. Single lesion of sarcoidosis presenting as cicatricial alopecia: a rare report from India. Int J Trichology . 2014 Apr;6(2):63-6.
 
Prohaska J et al. Scalp Sarcoidosis Presenting as Cicatricial Alopecia. J Am Osteopath Assoc.  2018 Dec 1;118(12):824-826. 
 
Conde K et al. Lupus Pernio in Chronic Sarcoidosis. Cureus 2021 Sep; 13(9): e18331.
 
Hubail et al. Lupus pernio (Besnier-Tenneson syndrome): A rare form of sarcoidosis. Dermatol Reports 2018 Oct 1; 10(2): 7696.
 
Gopikrishnan Anjaneyan and Rita Vora Lupus pernio without systemic involvement. Indian Dermatol Online J. 2013 Oct-Dec; 4(4): 314–317.
 
JAK INHIBITOR SAFETY
Hoisnard L et al (starts at 37:53). Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database. Sci Rep. 2022 May 3;12(1):7140
 
EYELASH TRICHOMEGALY WITH EGFR INHIBITORS
Inamadar S and Kumar NSP (starts at 59:03). Lady with Long Eyelashes… Int J Trichology. Mar-Apr 2022;14(2):71-72. 

Season 2, Episode 1 (Frontal fibrosing alopecia, Lichen planopilaris, Dissecting cellulitis)

Evidence Based Hair Podcast for the May 16, 2022 issue. 
STUDIES REFERENCED
 
FRONTAL FIBROSING ALOPECIA STUDIES
 
Arasu et al (starts at 3:40). Vitamin D status in patients with frontal fibrosing alopecia: A retrospective study. JAAD Int. 2022 Apr 18;7:129-130.
 
Sun et al (starts at 11:30). Extensive facial scarring after ablative laser resurfacing in a patient with frontal fibrosing alopecia. JAAD Case Rep. 2022 Mar 26;23:123-127
 
Lobato-Berezo et al (starts at 18:32). Pustular frontal fibrosing alopecia: a new variant within the folliculitis decalvans and lichen planopilaris phenotypic spectrum? Br J Dermatol. 2022 May;186(5):905-907.
 
Rocha VB et al (starts at 22:50). Uncommon subtypes of frontal fibrosing alopecia: retrospective analysis of clinical characteristics and prognosis. Anais Brasileiros de Dermatologia An Bras Dermatol. Mar-Apr 2022;97(2):260-262.
 
LICHEN PLANOPILARIS STUDIES
 
Diab R et al (starts at 30:17). Lichen planus and lichen planopilaris flare after COVID-19 vaccination. Dermatol Ther. 2022 Mar;35(3):e15283.
 
DISSECTING CELLULITIS STUDIES
 
Babalola et al (starts at 35:27). Refractory Dissecting Cellulitis of the Scalp Treated With Risankizumab. J Drugs Dermatol. 2022 Mar 1;21(3):313-314.
 
Awad A and Sinclair R (starts at 42:45). Treatment of dissecting cellulitis of the scalp with Tildrakizumab. Australas J Dermatol 2022 May 4
 
 

Season 1, Episode 12 (Season 1 Finale; Scalp Allergic Contact Dermatitis, PDL laser induced hair loss, Plaquenil Oral Pigmentation, Persistent Chemotherapy Induced Alopecia)

Recording of the Evidence Based Hair Podcast for the April 25, 2022 issue.
 
STUDIES REFERENCED
 
ALLERGIC CONTACT DERMATITIS STUDIES
Feryel A et al (starts at 3:51). Unusual clinical presentation of allergic contact dermatitis to topical minoxidil. Contact Dermatitis. 2022 Mar 28
Pham et al (starts at 12:18). Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens. Dermatitis. 2022 Mar 22.
 
PULSED DYE LASER AND HAIR LOSS IN INFANTILE HEMANGIOMAS
Yang et al (starts at 19:56). Risk factors of long-term alopecia after pulsed-dye laser treatment for infantile scalp hemangiomas: A retrospective study. J Dermatol. 2022 Apr 5.
Feldstein S et al. Can long-term alopecia occur after appropriate pulsed-dye laser therapy in hair-bearing sites? Pediatric dermatologists weigh in. Dermatol Surg. 2015 Mar;41(3):348-51.
 
ORAL PIGMENTATION FROM HYDROXYCHLOROQUINE
Silva PUJ et al (starts at 31:26). Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use: A scoping review. Medicine (Baltimore). 2022 Mar 18;101(11):e29044.
 
PERMANENT CHEMOTHERAPY INDUCED ALOPECIA
Lyakhovitsky A et al (starts at 37:38). Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil. JAAD Case Rep. 2022 Feb 17;22:64-67.
Vano-Galvan S et al. Safety of low dose oral minoxidil for hair loss: A multicenter study of 1404 patients. JAAD 2021; 84: 1644-51.
Sanabria B et al. Adverse effects of low dose oral minoxidil for androgenetic alopecia in 435 patients. JAAD 2021; 84: 1175-78.
Kolla et al (starts at 54:24). Permanent chemotherapy-induced alopecia presenting with erosive pustular dermatosis-like retention hyperkeratosis. JAAD Case Rep. 2022 Jan 6;21:77-79.
Yin et al (starts at 58:25). Dermatologist Awareness of Scalp Cooling for Chemotherapy-induced Alopecia. J Am Acad Dermatol. 2022 Mar 9;S0190-9622(22)00386-3
 

Season 1, Episode 11 (Scarring Alopecia - Frontal Fibrosing Alopecia and Lichen Planopilaris)

STUDIES REFERENCED
FRONTAL FIBROSING ALOPECIA & REPIGMENTATION:
Barreto TM et al (starts at 3:18). Atypical frontal fibrosing alopecia presentation in a male patient associated with spontaneous reversal of canities. J Eur Acad Dermatol Venereol. 2022 Mar 12
Defo D et al Repigmentation pilaire enbordure d’une alopecie frontale fibrosante. [Hair darkening close to a patch of frontal fibrosing alopecia]. Ann Dermatol Venereol 2006;133: 799–801
Pastor-Nieto et al. Localized grey hair repigmentation (canities reversal) in patients with frontal fibrosing alopecia. J Eur Acad Dermatol Venereol 2021; 35: e408–e410.
 
COSMETIC SURGERY AND RISK OF FRONTAL FIBROSING ALOPECIA:
Pham et al (starts at 9:00). The Association of Frontal Alopecia with a History of Facial and Scalp Surgical Procedures. Skin Appendage Disord. 2022 Jan;8(1):13-19.
Kossard and Shiell. Frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia. Int J Dermatol. 2005 Apr;44(4):321-3.
Chiang YZ et al. Lichen planopilaris following hair transplantation and face-lift surgery Br J Dermatol. 2012 Mar;166(3):666-370.
 
HAIR TRANSPLANT SURGERY FOR PATIENTS WITH FFA:
Vano-Galvan S et al (starts at 14:30). Hair transplant in frontal fibrosing alopecia: A multicenter review of 51 patients. J Am Acad Dermatol. 2019 Sep;81(3):865-866.
Arasu et al (starts at 22:13). Scalp reduction surgery does not reactivate frontal fibrosing alopecia: A case report. Dermatol Ther. 2022 Mar 16;e15451.
 
LICHEN PLANOPILARIS AND CHECKPOINT INHIBITORS
Garcia-Melendo C et al (starts at 38:59). Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatol Ther. 2022 Feb 17;e15388.
Uthayakumar AK et al. Severe progressive scarring pembrolizumab-induced lichen planopilaris in a patient with metastatic melanoma. Australas J Dermatol. 2021 Aug;62(3):403-406.
Cogen et al. Lichen planopilaris associated with pembrolizumab in a patient with metastatic melanoma. JAAD Case Rep . 2018 Jan 16;4(2):132-134.
Dominguez-Santas M et al. Avelumab-induced lichen planopilaris, a novel association. Int J Dermatol. 2021 Oct;60(10):e414-e416.

Season 1, Episode 10 (Telogen Effluvium, Tinea Capitis, Trichotillomania)

REFERENCES CITED IN THIS EPISODE (and TIME STAMP)
 
TELOGEN EFFLUVIUM
 
Monari et al (starts at 4:20). Post-SARS-CoV-2 Acute Telogen Effluvium: An Expected Complication. J Clin Med. 2022 Feb 24;11(5):1234.
Muller-Ramos P et al. Post-COVID-19 hair loss: prevalence and associated factors among 5,891 patients. Int J Dermatol 2022 Jan 26.
Guarnieri G et al (starts at 9:07). Relationship between hair shedding and systemic inflammation in COVID-19 pneumonia. Ann Med. 2022;54(1):869-874.
Wong-Chew RM et al (starts at 13:11). Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City. Ther Adv Infect Dis. 2022 Jan 11;9:20499361211069264.
Fernandez-de-Las-Penas et al. Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J Clin Med. 2022 Jan 14;11(2):413.
Ali MD (starts at 18:49). Proton pump inhibitors' use and risk of iron deficiency anaemia: a systematic review and meta-analysis. Curr Rev Clin Exp Pharmacol. 2022 Mar 7. 
 
 
TRICHOTILLOMANIA AND PEDIATRIC EMOTIONAL HEALTH
Wang et al (starts at 24:29). Trichotillomania occurs during the COVID-19 pandemic in an adolescent. World J Pediatr. 2022 Feb 28;1-2.
Saunders NR et al. Utilization of Physician-Based Mental Health Care Services Among Children and Adolescents Before and During the COVID-19 Pandemic in Ontario, Canada. April 2022 JAMA Pediatrics.2022 Apr 1;176(4):e216298.
Racine  N et al. Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis JAMA Pediatr. 2021;175(11):1142-1150.
Pathoulas et al. Cross-sectional survey examining skin picking and hair pulling disorders during the COVID-19 pandemic. J Am Acad Dermatol. 2021 Mar;84(3):771-773.
Öner Ü. Children with trichotillomania in COVID-19 outbreak. J Cosmet Dermatol. 2021;20(7):1967–8.
 
 
TINEA CAPITIS
Salah NB et al (starts at 31:19). Erythema nodosum in patients with kerion of scalp. Clin Exp Dermatol. 2021 Dec;46(8):1577-1578.
Blake T et al. Erythema nodosum - a review of an uncommon panniculitis. Dermatol Online J. 2014 Apr 16;20(4):22376.
Kumar P and Pandhi D (starts at 41:09). Role of Trichoscopy in the Management of Tinea Capitis in Two  Infants: A Case Report. J Cutan Aesthet Surg. Oct-Dec 2021;14(4):443-445.
 

Season 1, Episode 9 (Alopecia Areata and Androgenetic Alopecia)

STUDIES HIGHLIGHTED
ALOPECIA AREATA
King B et al (starts at 3:27). Two Phase 3 Trials of Baricitinib for Alopecia Areata. N Engl J Med. 2022 Mar 26.
Fenentinos P et al (starts at 16:24). Assessing the role of stressful life events in the induction and recurrence of alopecia areata: a case-control study. J Am Acad Dermatol.  2022 Mar 24;S0190-9622(22)00526-6.
Macbeth A et al (starts at 21:14). The associated burden of mental health     conditions in alopecia areata: A population-based study in UK primary care. Br J Dermatol.  2022 Feb 14.
Senna M et al (starts at 29:06). Predictors of Quality of Life in Patients with Alopecia Areata. J Invest Dermatol 2022 Mar 21;S0022-202X
 
 
ANDROGENETIC ALOPECIA
Ghafoor R et al (starts at 39:15). Association of androgenetic alopecia and severity of coronavirus disease 2019. J Cosmet Dermatol. 2022 Mar;21(3):874-879.
Baghani M et al (starts at 40:57). Androgenetic alopecia and COVID-19: Is there a clinical connection? J Cosmet Dermatol . 2022 Feb;21(2):420-425.
Veskovic D et al (starts at 42:04). Association of androgenetic alopecia with a more severe form of COVID-19 infection. Ir J Med Sci. 2022 Mar 23;1-6.
 

Season 1, Episode 8 (Minoxidil in Breastfeeding, Prepubertal Hair Loss, Trichorrhexis nodosa)

Recording of the Evidence Based Hair Podcast for the March 28, 2022 issue.
 
 
 
STUDIES HIGHLIGHTED
 
Trueb RM et al (starts at 3:27). Minoxidil-induced hypertrichosis in a breastfed infant. J Eur Acad Dermatol Venereol. 2022 Mar;36(3):e224-e225.
 
Gangal et al (starts at 7:08). Mask-associated acquired trichorrhexis nodosa of the beard. JAAD Case Rep. 2022 Mar;21:101-102.
 
Trueb RM et al. Prepubertal pattern hair loss (starts at  13:38) Clin Exp Dermatol. 2022 Jan;47(1):173-175.):24-30
 
Katayama S et al (starts at 17:00). Rapidly Progressive Hair Loss May Be the Only Sign of Syphilis. Am J Med 2022 Feb 22;S0002-9343(22)00130-9.
 
Kolla et al (starts at 32:34). Dermatologists' knowledge of dermoscopic features in hair and nail disorders. J Eur Acad Dermatol Venereol. 2022 Feb 11.
 
Rutnin S et al (starts at 37:32)). Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study. Skin Appendage Disord. 2022 Jan;8(1):24-30.
 
Xie et al (starts at 42:27). Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis. Cell Stem Cell 2022 Jan 6;29):

Season 1, Episode 7 (Scarring Alopecia)

STUDIES HIGHLIGHTED
FFA STUDIES
Dubin C et al (starts at 2:50). Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement. J Am Acad Dermatol. 2022 Mar;86(3):551-562. doi: 10.1016/j.jaad.2021.05.016
Starace et al (starts at 12:31). Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multicenter Study of the International Dermoscopy Society. Dermatol Pract Concept. 2022 Jan 1;12(1):e2022080
Rayinda T et al (starts at 17:25). Clinical characteristics of male frontal fibrosing alopecia: a single-centre case series from London, UK. Br J Dermatol. 2022 Jan;186:195-197
 
LPP STUDIES
Moussa A et al (starts at 21:51). Treatment of lichen planopilaris with baricitinib: A retrospective study. J Am Acad Dermatol. 2022 Feb 21;S0190-9622(22)00338-3
Mostafa N et al (starts at 25:24). Mycophenolate mofetil and lichen planopilaris: systematic review and meta-analysis. J Dermatolog Treat . 2022 Feb;33(1):369-372.
 
FOLLICULITIS DECALVANS STUDIES
Iorizzo M et al (starts at 27:25). Refractory folliculitis decalvans treated with adalimumab: a case series of 23 patients. J Am Acad Dermatol 2022 Mar 1;S0190-9622(22)00358-9.
 
CCCA STUDIES
Roche FC et al (starts at 33:01). Association of type 2 diabetes with central centrifugal cicatricial alopecia: A follow-up study. J Am Acad Dermatol. 2022 Mar;86(3):661-662.
Collins MS et al (starts at 37:45). Increased risk of vitamin D deficiency and insufficiency in Black patients with central centrifugal cicatricial alopecia. J Am Acad Dermatol . 2022 Feb 15;S0190-9622(22)00272-9.
Powe et al.  Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 2013 Nov 21;369(21):1991-2000.
Brown L et al. The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report. BMC Proc . 2018 May 9;12(Suppl 6):6.
 
 

Season 1, Episode 6 (Telogen Effluvium, Tinea Capitis, Trichotillomania, Traction Alopecia)

STUDIES HIGHLIGHTED IN THIS EPISODE
 
TELOGEN EFFLUVIUM
 
Lytvyn et al (starts at 2:15). Comparing the frequency of isotretinoin-induced hair loss at

Season 1, Episode 5 (Androgenetic Alopecia and Alopecia Areata)

STUDIES HIGHLIGHTED IN THIS EPISODE
Qui Y et al (starts at 2:41). Systematic Review and Meta-analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia. Acta Derm Venereol. 2022 Feb 8;102:adv00645
 
Gupta AK et al (starts at 8:38). Relative Efficacy of Minoxidil and the 5-alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis. JAMA Dermatol. 2022 Feb 2:e215743
 
Plante J (starts at 23:13). Perifollicular inflammation and follicular spongiosis in androgenetic alopecia. J Am Acad Dermatol 2022Feb;86(2):437-438.
 
Qiu et al (starts at 28:04). Efficacy assessment for low-level laser therapy in the treatment of androgenetic alopecia: a real-world study on 1383 patients. Lasers Med Sci. 2022
 
Yale K et al (starts at 33:53). A year in review: A cross-sectional study of alopecia areata and risk of COVID-19 infection, hospitalization, and mortality from March 2020 -February 2021 Int J Dermatol. 2022 Mar;61(3):e81-e83.
 
Lee MM (starts at 38:10). Alopecia areata following COVID-19 vaccination: vaccine-induced autoimmunity? Int J Dermatol. 2022 Feb
 
Bardazzi et al (starts at 39:04). New insights on alopecia areata during COVID-19 pandemic: when infection or vaccination seems to play a role. J Cosmet Dermatol. 2022 Feb 188.
 
Scollan M et al (starts at 41:08). Alopecia areata after SARS-CoV-2 vaccination JAAD Case Rep. 2022 Feb;20:1-5.
 
Harries M et al (starts at 43:42). The epidemiology of alopecia areata: a population-based cohort study in UK primary care. Br J Dermatol. 2022 Feb;186(2):257-265.
 
Gutierrez Y et al (starts at 49:38). Alopecia areata in the United States: a ten-year analysis of patient characteristics, comorbidities, and treatment patterns. Dermatol Online J. 2021 Oct 15;27(10)