Evidence Based Hair

Kavadya T and Mysore V (starts at 5:24). Role of Smoking in Androgenetic Alopecia: A Systematic Review. Int J Trichology. 2022 Mar-Apr; 14(2): 41–48.
 
Mosley JG and Gibbs AC (starts at 6;30). Premature grey hair and hair loss among smokers: a new opportunity for heatlh education? British Medical Journal 1996; 313: 1616.
 
Su LH and Chen T H-H (starts at 7:38) Association of Androgenetic Alopecia with Smoking and Its Prevalence Among Asian Men. Archives of Dermatology 2007 143; 1401-1406.
 
 
 
Calvao J et al (starts at 9:16). Finasteride and Floppy Iris Syndrome: What Role Can the Dermatologist Play? Int J Trichology. May-Jun 2022;14(3):115-116.
 
Ting H-C et al (starts at 14:04). Association between alopecia areata and retinal diseases: A nationwide population-based cohort study. J Am Acad Dermatol . 2021 Nov 1;S0190-9622(21)02735-3.
 
Thatiparthi A et al (starts at 15:56). Inflammatory ocular comorbidities in alopecia areata: a retrospective cohort study of a single academic center. J Am Acad Dermatol. 2022 Jun 16;S0190-9622(22)01009-X
 
 
Albela H et al (starts at 19:32). Efficacy and Tolerability of Methotrexate in the Treatment of Severe Paediatric Alopecia Areata. Skin Appendage Disord. 2022 May;8(3):206-210.
 
 
Barton V et al (starts at 24:20). Treatment of pediatric alopecia areata: A systematic review. J Am Acad Dermatol. 2022 Jun;86(6):1318-1334.
 
 
Gambardella A, et al (starts at 29:18). Dual Efficacy of Upadacitinib in 2 Patients With Concomitant Severe Atopic Dermatitis and Alopecia Areata. Dermatitis 2021; 32: e85–e86.
 
Cantelli M et al (starts at 31:35). Upadacitinib improved alopecia areata in a patient with atopic dermatitis: a case report. Dermatol Ther. 2022; 1: e15346 
 
Asfour et al (starts at 32:35). Concurrent chronic alopecia areata and severe atopic dermatitis successfully treated with upadacitinib.  Int J Dermatol. 2022 Jun 20.
 
Gori N et al (starts at 33:53). Assessment of alopecia areata universalis successfully treated with upadacitinib. Int J Dermatol. 2022 Jul 2.
 
 
Conclusions and Summary (starts at 37:24)

JAK KINASE INHIBITORS AND SKIN CANCER
Jalles et al (starts at 5:29). Skin cancers under Janus kinase inhibitors: A World Health Organization drug safety database analysis. Therapie. 2022 May 7;S0040-5957(22)00092-0.
 
ISOTRETINOIN LAB MONITORING
Xia E et al (starts at 13:36). Isotretinoin Laboratory Monitoring in Acne Treatment: A Delphi Consensus Study. JAMA Dermatol. 2022 Jun 15.
 
ISOTRETINOIN & SURGERY
Davis and Perkins (starts at 18:28). Oral isotretinoin (Roaccutane) use during incisional surgery: safe or risky? Case Reports Plast Surg Hand Surg. 2022 May 13;9(1):131-134.
Spring L et al (starts at 20:17). Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations. JAMA Dermatol. 2017 Aug 1;153(8):802-809.
Mysore V et al. Standard Guidelines of Care: Performing Procedures in Patients on or Recently Administered with Isotretinoin J Cutan Aesthet Surg. 2017 Oct-Dec; 10(4): 186–194.
 
CONGENITAL TRIANGULAR ALOPECIA
Shimrada K et al (starts at 23:57). Atypical Localization of Congenital Triangular Alopecia Associated with Down's Syndrome. Indian J Dermatol. 2022 Jan-Feb; 67(1): 94
Starace M et al (starts at 25:40). Atypical Presentation of Congenital Triangular Alopecia: A Case Series in Italy. Dermatol Pract Concept Oct 2020.
 
HYDROXYCHLOROQUINE DOSING
Chen R et al (ssarts at 30:00). Impact of an Electronic Decision Support Tool to Improve Ophthalmic Safety in Hydroxychloroquine Prescribing Practices Ophthalmic Surg Lasers Imaging Retina. 2022 Jun;53(6):310-316.
Melles & Marmor (starts at 31:24). The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy. JAMA Ophthalmol. 2014;132(12):1453–1460.

The third Monday of the month is dedicated to studies in scarring alopecia.
 
LICHEN PLANOPILARIS
 
Kahjoogh et al (starts at 5:34). Efficacy, safety, tolerability and satisfaction of N-acetylcysteine and pentoxifylline in lichen planopilaris patients under treatment with topical clobetasol: a triple arm blinded randomized controlled trial. Dermatol Ther. 2022 Jun 15
 
HYDROXYCHLOROQUINE
Beatriz Samões et al (starts at 24:05). Hydroxychloroquine induced melanosis. Reumatol Clin (Engl Ed). Jun-Jul 2022;18(6):377-378.
 
 
LINEAR SCLERODERMA
de Marsillac P et al (starts at 27:53). Clinical, epidemiological, trichoscopic and histopathological features of linear morphea on the scalp. J Eur Acad Dermatol Venereol. 2022 Jun 13. doi: 10.1111/jdv.18323. Online ahead of print
 
Ulc E et al (starts at 40:40). Therapeutic and Reconstructive Management Options in Scleroderma (Morphea) en Coup de Sabre in Children and Adults. A Systematic Literature Review. J Clin Med.
 
 
DISSECTING CELLULITIS
 
Melo DF et al (starts at 42:41). Dissecting cellulitis in women: a retrospective multicenter study with 17 patients. Int J Dermatol. 2022 May 15. doi: 10.1111/ijd.16271. Online ahead of print. May;86(5):e207-e208.
Ward N et al (starts at 48:03). Dissecting cellulitis of the scalp associated with peripheral and axial spondyloarthritis: report of a case and review of the literature. Clin Rheumatol 2022 Apr 23.

DYSTROPHIC ANAGEN EFFLUVIUM IN COVID 19 SHEDDING
Shanshal M (start 7:52). COVID-19 related anagen effluvium. J Dermatolog Treat. 2022 Mar;33(2):1114-1115.
Anna Carolina Miola et al (starts 9:45). Early-onset effluvium secondary to COVID-19: Clinical and histologic characterization. J Am Acad Dermatol. 2022
 
ALTERNATE DAY IRON DOSING
Lale Aydın Kaynar et al (starts 12:57). Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia. Ann Hematol. 2022 Apr 23.
Stoffel NU et al (starts 17:23). Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533.
Mehta S et al (starts 19:03). A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. J Assoc Physicians India. 2020 May;68(5):39-41.
 
INTRAVENOUS IRON
Aratsu et al (starts 22:57). Analysis of Adverse Events and Intravenous Iron Infusion Formulations in Adults With and Without Prior Infusion Reactions. JAMA Netw Open. 2022 Mar; 5(3): e224488.
 
SSRI AND HAIR LOSS
Etiman M et al (starts 29:44). Risk of hair loss with different antidepressants: a comparative retrospective cohort study. Int Clin Psychopharmacol 2018 Jan;33(1):44-48.
Pejcic and Paudel (starts 31:17). Alopecia associated with the use of selective serotonin reuptake inhibitors: Systematic review. Psychiatry Res. 2022 May 10;313:114620. ;86(5):e207-e208.
 
TRACTION ALOPECIA
Beach RA (starts 35:56). Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy. Dermatol Ther. 2018 Nov;31(6):e12707.
Kim and Craiglow (starts 36:38). Treatment of traction alopecia with oral minoxidil. JAAD Case Rep. 2022 Apr 1;23:112-113.
 
N ACETYL CYSTEINE IN TRICHOTILLOMANIA
Grant JE et al (starts 44:20). Arch Gen Psychiatry 2009
Bloch MH et al (starts 46:05) N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial. J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):231-40.
Popova L and Mancuso J (starts 48:09). Dramatic Improvement of Trichotillomania with 6 Months of Treatment With N-Acetylcysteine. Glob Pediatr Health. 2022 Mar 14;9:2333794X221086576.

ANDROGENETIC ALOPECIA STUDIES
Sanabria et al (starts at 4:40). Prospective cardiovascular evaluation with 24-h Holter and 24-h ambulatory blood pressure monitoring in men using 5 mg oral minoxidil for androgenetic alopecia. J Am Acad Dermatol. 2022 May 18;
Klein E et al (starts at 13:40). Comparing combination low-dose oral minoxidil and topical minoxidil with oral minoxidil alone for the treatment of non-scarring alopecia; a retrospective chart review. J Cosmet Dermatol. 2022 Jun 1.
Cao L et al (starts at 21:19). Nailfold capillaroscopy alterations in androgenetic alopecia: A cross-sectional study. Indian J Dermatol Venereol Leprol. 2022 Feb 28;1-7. doi: 10.25259/IJDVL_714_2021.
Emmanuel Sánchez-Meza et al (starts at 28:17). Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study. J Eur Acad Dermatol Venereol. 2022 Jun 1. doi: 10.1111/jdv.18285. 
David Saceda-Corralo et al. Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia. Int J Trichology. 2017 Jul-Sep; 9(3): 143–145.
Liamsombut S et al (starts at 34:45). Sleep quality in men with androgenetic alopecia. Sleep and Breathing. 2022 Apr 25.
 
 
ALOPECIA AREATA STUDIES
Anna Waśkiel-Burnat et al (starts at 41:33). Patients with alopecia areata are at risk of endothelial dysfunction: results of a case-control study. Clin Exp Dermatol. 2022 Mar 31.
Conic et al. Prevalence of cardiac and metabolic diseases among patients with alopecia areata.J Eur Acad Dermatol Venereol . 2021 Feb;35(2):e128-e129.
Youssef S et al (starts at 48:28). Tofacitinib Therapy for Alopecia Areata is not Associated with Adverse Events during COVID-19 Infection. J Am Acad Dermatol. 2022 May 9;S0190-9622(22)00795-2.
McKenzie P et al (starts at 53:32). Evaluation of the Prevalence and Incidence of Pediatric Alopecia Areata Using Electronic Health Record Data. JAMA Dermatol. 2022 May 1;158(5):547-551.

Recording of the Evidence Based Hair Podcast for the May 23, 2022 issue. 
ORAL MINOXIDIL USE IN PEDIATRIC PATIENTS
 
Nicolas-Ruanes et al (starts at 4:00). Low-dose oral minoxidil for treatment of androgenetic alopecia and telogen effluvium in a pediatric population: A descriptive study. J Am Acad Dermatol. 2022 Apr 26;
 
Jerjen R et al. Low-dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome. Br J Dermatol. 2021;184(5):977-978.
 
 
ORAL MINOXIDIL COMPOUNDING ERRORS
 
Moreno-Arrones OM et al (starts at 9:06). Serious Adverse effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment. Actas Dermosifiliogr. 2022 May 12;S0001-7310(22)00414-8.
 
 
DOXYCYCLINE SKIN PIGMENTATION
 
Afrin et al (starts at 17:15). Doxycycline-Associated Hyperpigmentation: A Case Report and Literature Review. Cureus.  2022 Apr 2;14(4):e23754.
 
 
SCALP SARCOIDOSIS
Kim JC and Lee ES (starts at 22:06). Unusual Case of Scalp Sarcoidosis with Alopecia: An Only Manifestation of Cutaneous Sarcoidosis without Systemic Involvement. Ann Dermatol. 2022 Apr;34(2):154-156.
 
Long T et al. Severe scalp sarcoidosis in an unlikely patient. JAAD Case Rep. 2020 Apr 24;6(11):1165-1166.
 
House NS et al. Sarcoidosis-induced alopecia.Dermatol Online J 2012 Aug 15;18(8):4.  
 
Ghosh A et al. Single lesion of sarcoidosis presenting as cicatricial alopecia: a rare report from India. Int J Trichology . 2014 Apr;6(2):63-6.
 
Prohaska J et al. Scalp Sarcoidosis Presenting as Cicatricial Alopecia. J Am Osteopath Assoc.  2018 Dec 1;118(12):824-826. 
 
Conde K et al. Lupus Pernio in Chronic Sarcoidosis. Cureus 2021 Sep; 13(9): e18331.
 
Hubail et al. Lupus pernio (Besnier-Tenneson syndrome): A rare form of sarcoidosis. Dermatol Reports 2018 Oct 1; 10(2): 7696.
 
Gopikrishnan Anjaneyan and Rita Vora Lupus pernio without systemic involvement. Indian Dermatol Online J. 2013 Oct-Dec; 4(4): 314–317.
 
JAK INHIBITOR SAFETY
Hoisnard L et al (starts at 37:53). Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database. Sci Rep. 2022 May 3;12(1):7140
 
EYELASH TRICHOMEGALY WITH EGFR INHIBITORS
Inamadar S and Kumar NSP (starts at 59:03). Lady with Long Eyelashes… Int J Trichology. Mar-Apr 2022;14(2):71-72. 

Evidence Based Hair Podcast for the May 16, 2022 issue. 
STUDIES REFERENCED
 
FRONTAL FIBROSING ALOPECIA STUDIES
 
Arasu et al (starts at 3:40). Vitamin D status in patients with frontal fibrosing alopecia: A retrospective study. JAAD Int. 2022 Apr 18;7:129-130.
 
Sun et al (starts at 11:30). Extensive facial scarring after ablative laser resurfacing in a patient with frontal fibrosing alopecia. JAAD Case Rep. 2022 Mar 26;23:123-127
 
Lobato-Berezo et al (starts at 18:32). Pustular frontal fibrosing alopecia: a new variant within the folliculitis decalvans and lichen planopilaris phenotypic spectrum? Br J Dermatol. 2022 May;186(5):905-907.
 
Rocha VB et al (starts at 22:50). Uncommon subtypes of frontal fibrosing alopecia: retrospective analysis of clinical characteristics and prognosis. Anais Brasileiros de Dermatologia An Bras Dermatol. Mar-Apr 2022;97(2):260-262.
 
LICHEN PLANOPILARIS STUDIES
 
Diab R et al (starts at 30:17). Lichen planus and lichen planopilaris flare after COVID-19 vaccination. Dermatol Ther. 2022 Mar;35(3):e15283.
 
DISSECTING CELLULITIS STUDIES
 
Babalola et al (starts at 35:27). Refractory Dissecting Cellulitis of the Scalp Treated With Risankizumab. J Drugs Dermatol. 2022 Mar 1;21(3):313-314.
 
Awad A and Sinclair R (starts at 42:45). Treatment of dissecting cellulitis of the scalp with Tildrakizumab. Australas J Dermatol 2022 May 4
 
 

Recording of the Evidence Based Hair Podcast for the April 25, 2022 issue.
 
STUDIES REFERENCED
 
ALLERGIC CONTACT DERMATITIS STUDIES
Feryel A et al (starts at 3:51). Unusual clinical presentation of allergic contact dermatitis to topical minoxidil. Contact Dermatitis. 2022 Mar 28
Pham et al (starts at 12:18). Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens. Dermatitis. 2022 Mar 22.
 
PULSED DYE LASER AND HAIR LOSS IN INFANTILE HEMANGIOMAS
Yang et al (starts at 19:56). Risk factors of long-term alopecia after pulsed-dye laser treatment for infantile scalp hemangiomas: A retrospective study. J Dermatol. 2022 Apr 5.
Feldstein S et al. Can long-term alopecia occur after appropriate pulsed-dye laser therapy in hair-bearing sites? Pediatric dermatologists weigh in. Dermatol Surg. 2015 Mar;41(3):348-51.
 
ORAL PIGMENTATION FROM HYDROXYCHLOROQUINE
Silva PUJ et al (starts at 31:26). Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use: A scoping review. Medicine (Baltimore). 2022 Mar 18;101(11):e29044.
 
PERMANENT CHEMOTHERAPY INDUCED ALOPECIA
Lyakhovitsky A et al (starts at 37:38). Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil. JAAD Case Rep. 2022 Feb 17;22:64-67.
Vano-Galvan S et al. Safety of low dose oral minoxidil for hair loss: A multicenter study of 1404 patients. JAAD 2021; 84: 1644-51.
Sanabria B et al. Adverse effects of low dose oral minoxidil for androgenetic alopecia in 435 patients. JAAD 2021; 84: 1175-78.
Kolla et al (starts at 54:24). Permanent chemotherapy-induced alopecia presenting with erosive pustular dermatosis-like retention hyperkeratosis. JAAD Case Rep. 2022 Jan 6;21:77-79.
Yin et al (starts at 58:25). Dermatologist Awareness of Scalp Cooling for Chemotherapy-induced Alopecia. J Am Acad Dermatol. 2022 Mar 9;S0190-9622(22)00386-3
 

STUDIES REFERENCED
FRONTAL FIBROSING ALOPECIA & REPIGMENTATION:
Barreto TM et al (starts at 3:18). Atypical frontal fibrosing alopecia presentation in a male patient associated with spontaneous reversal of canities. J Eur Acad Dermatol Venereol. 2022 Mar 12
Defo D et al Repigmentation pilaire enbordure d’une alopecie frontale fibrosante. [Hair darkening close to a patch of frontal fibrosing alopecia]. Ann Dermatol Venereol 2006;133: 799–801
Pastor-Nieto et al. Localized grey hair repigmentation (canities reversal) in patients with frontal fibrosing alopecia. J Eur Acad Dermatol Venereol 2021; 35: e408–e410.
 
COSMETIC SURGERY AND RISK OF FRONTAL FIBROSING ALOPECIA:
Pham et al (starts at 9:00). The Association of Frontal Alopecia with a History of Facial and Scalp Surgical Procedures. Skin Appendage Disord. 2022 Jan;8(1):13-19.
Kossard and Shiell. Frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia. Int J Dermatol. 2005 Apr;44(4):321-3.
Chiang YZ et al. Lichen planopilaris following hair transplantation and face-lift surgery Br J Dermatol. 2012 Mar;166(3):666-370.
 
HAIR TRANSPLANT SURGERY FOR PATIENTS WITH FFA:
Vano-Galvan S et al (starts at 14:30). Hair transplant in frontal fibrosing alopecia: A multicenter review of 51 patients. J Am Acad Dermatol. 2019 Sep;81(3):865-866.
Arasu et al (starts at 22:13). Scalp reduction surgery does not reactivate frontal fibrosing alopecia: A case report. Dermatol Ther. 2022 Mar 16;e15451.
 
LICHEN PLANOPILARIS AND CHECKPOINT INHIBITORS
Garcia-Melendo C et al (starts at 38:59). Extensive lichen planopilaris as exclusive lichenoid reaction secondary to pembrolizumab in a patient with metastatic melanoma. Dermatol Ther. 2022 Feb 17;e15388.
Uthayakumar AK et al. Severe progressive scarring pembrolizumab-induced lichen planopilaris in a patient with metastatic melanoma. Australas J Dermatol. 2021 Aug;62(3):403-406.
Cogen et al. Lichen planopilaris associated with pembrolizumab in a patient with metastatic melanoma. JAAD Case Rep . 2018 Jan 16;4(2):132-134.
Dominguez-Santas M et al. Avelumab-induced lichen planopilaris, a novel association. Int J Dermatol. 2021 Oct;60(10):e414-e416.

REFERENCES CITED IN THIS EPISODE (and TIME STAMP)
 
TELOGEN EFFLUVIUM
 
Monari et al (starts at 4:20). Post-SARS-CoV-2 Acute Telogen Effluvium: An Expected Complication. J Clin Med. 2022 Feb 24;11(5):1234.
Muller-Ramos P et al. Post-COVID-19 hair loss: prevalence and associated factors among 5,891 patients. Int J Dermatol 2022 Jan 26.
Guarnieri G et al (starts at 9:07). Relationship between hair shedding and systemic inflammation in COVID-19 pneumonia. Ann Med. 2022;54(1):869-874.
Wong-Chew RM et al (starts at 13:11). Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City. Ther Adv Infect Dis. 2022 Jan 11;9:20499361211069264.
Fernandez-de-Las-Penas et al. Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J Clin Med. 2022 Jan 14;11(2):413.
Ali MD (starts at 18:49). Proton pump inhibitors' use and risk of iron deficiency anaemia: a systematic review and meta-analysis. Curr Rev Clin Exp Pharmacol. 2022 Mar 7. 
 
 
TRICHOTILLOMANIA AND PEDIATRIC EMOTIONAL HEALTH
Wang et al (starts at 24:29). Trichotillomania occurs during the COVID-19 pandemic in an adolescent. World J Pediatr. 2022 Feb 28;1-2.
Saunders NR et al. Utilization of Physician-Based Mental Health Care Services Among Children and Adolescents Before and During the COVID-19 Pandemic in Ontario, Canada. April 2022 JAMA Pediatrics.2022 Apr 1;176(4):e216298.
Racine  N et al. Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis JAMA Pediatr. 2021;175(11):1142-1150.
Pathoulas et al. Cross-sectional survey examining skin picking and hair pulling disorders during the COVID-19 pandemic. J Am Acad Dermatol. 2021 Mar;84(3):771-773.
Öner Ü. Children with trichotillomania in COVID-19 outbreak. J Cosmet Dermatol. 2021;20(7):1967–8.
 
 
TINEA CAPITIS
Salah NB et al (starts at 31:19). Erythema nodosum in patients with kerion of scalp. Clin Exp Dermatol. 2021 Dec;46(8):1577-1578.
Blake T et al. Erythema nodosum - a review of an uncommon panniculitis. Dermatol Online J. 2014 Apr 16;20(4):22376.
Kumar P and Pandhi D (starts at 41:09). Role of Trichoscopy in the Management of Tinea Capitis in Two  Infants: A Case Report. J Cutan Aesthet Surg. Oct-Dec 2021;14(4):443-445.